以质量求发展，以服务铸品牌

Journal of Nursing ›› 2022, Vol. 29 ›› Issue (2): 35-39.doi: 10.16460/j.issn1008-9969.2022.02.035

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Best Evidence Summary of Management of Gastrointestinal Symptoms in Patients with Nasopharyngeal Carcinoma Undergoing Chemotherapy or Radiotherapy

ZHANG Yu, LI Wan-dan, LUO Ying-xia, XIE Yang-wei   

  1. Dept. of Radiation Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
  • Received:2021-07-04 Online:2022-01-25 Published:2022-02-15

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Abstract: Objective To evaluate and summarize the best evidence of management of gastrointestinal symptoms in patients with nasopharyngeal carcinoma undergoing chemotherapy or radiotherapy, and to provide reference for clinical nursing staff of management of gastrointestinal symptoms. Methods Based on the 6S hierarchical evidence pyramid, the top-down retrieval from the top-level resources was conducted by computer from the inception to March 26, 2021. Results A total of 16 articles were found, including 6 guidelines, 8 systematic reviews, 2 evidence summaries, and 22 pieces of evidence were summarized. Conclusion The current best evidence for the management of gastrointestinal symptoms in patients with nasopharyngeal carcinoma undergoing chemotherapy and radiotherapy is summarized, including the prevention and treatment of oral mucositis, taste changes or loss of taste, and the management of nausea and vomiting during chemotherapy and radiotherapy.

Key words: chemotherapy or radiotherapy, nasopharyngeal carcinoma, digestive tract symptom, nutrition, evidence to summarize

CLC Number: 

  • R473.76
[1] Jiang L, Huang C, Gan Y, et al.Radiation-induced Late Dysphagia after Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma Patients: A Dose-volume Effect Analysis[J]. Scientific Reports, 2018, 8(1):16396. DOI: 10.1038/s41598-018-34803-y.
[2] Wang F, Jiang C, Ye Z, et al.Efficacy and Safety of Nimotuzumab with Neoadjuvant Chemotherapy Followed by Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma[J].Oncotarget,2017,8(43):75544-75556. DOI: 10.18632/oncotarget. 17357.
[3] Crichton M, Marshall S, Marx W, et al.Efficacy of Ginger (Zingiber Officinale) in Ameliorating Chemotherapy-induced Nausea and Vomiting and Chemotherapy-related Outcomes: A Systematic Review Update and Meta-analysis[J]. Journal of the Academy of Nutrition and Dietetics,2019,119(12):2055-2068.DOI: 10.1016/j. jand. 2019.06.009.
[4] Grossberg AJ, Chamchod S, Fuller CD, et al.Association of Body Composition with Survival and Locoregional Control of Radiotherapy-treated Head and Neck Squamous Cell Carcinoma[J]. JAMA Oncology, 2016, 2(6):782-789.DOI: 10.1001/jamaoncol. 2015.6339.
[5] Brouwers MC, Browman GP, Burgers JS, et al. AGREEII-Users Manual and 23-item Instrument[EB/OL].(2017-10-15)[2021-04-01].https://www.agreetrust.org/about -the -agree - enterprise/introduction-to-agree-ii/.pdf.
[6] 熊俊,陈日新.系统评价/Meta分析方法学质量的评价工具AMSTAR[J].中国循证医学杂志,2011,11(9):1084-1089.DOI:10.3969/j.issn.1672-2531.2011.09.017.
[7] 王青春,胡雁. JBI证据预分级及证据推荐级别系统(2014版)[J].护士进修杂志,2015,30(11):964-967.DOI:10.16821/j. cnki. hsjx. 2015.11.002.
[8] Roila F, Molassiotis A, Herrstedt J, et al.2016 MASCC and ESMO Guideline Update for the Prevention of Chemotherapy-and Radiotherapy-induced Nausea and Vomiting and of Nausea and Vomiting in Advanced Cancer Patients[J]. Ann Oncol,2016,27(5):v119-v133.DOI:10.1093/annonc/ mdw270.
[9] Cohen EE, LaMonte SJ, Erb NL, et al. American Cancer Society Head and Neck Cancer Survivorship Care Guideline[J].CA Cancer J Clin,2016,66(3):203-39.DOI:10.3322/caac. 21343.
[10] Nekhlyudov L, Lacchetti C, Davis NB, et al.Head and Neck Cancer Survivorship Care Guideline: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Cancer Society Guideline[J]. J Clin Oncol,2017,35(14):1606-1621.DOI:10.1200/JCO. 2016.71.8478.
[11] Pfister DG, Spencer S, Adelstein D, et al.Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology[J]. J Natl Compr Canc Netw, 2020, 18(7):873-898. DOI: 10.6004/jnccn.2020.0031.
[12] Elad S, Cheng KKF, Lalla RV, et al.Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy[J]. Cancer, 2020,126(19):4423-4431.DOI: 10.1002/cncr. 33100.
[13] Hesketh PJ, Kris MG, Basch E, et al.Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update[J]. J Clin Oncol, 2017, 35(28):3240-3261. DOI:10.1200/JCO.2017.74.4789.
[14] Davy C, Heathcote S.A Systematic Review of Interventions to Mitigate Radiotherapy-induced Oral Mucositis in Head and Neck Cancer Patients[J]. Support Care Cancer, 2021,29(4):2187-2202.DOI:10.1007/s00520-020-05548-0.
[15] 王旭梅,王莉,吴心怡,等.穴位刺激在预期性化疗相关恶心呕吐干预效果中的Meta分析[J].中华现代护理杂志,2020,26(30):4200-4209.DOI:10.3760/cma.j.cn115682-20191223-04710.
[16] Toniolo J, Delaide V, Beloni P.Effectiveness of Inhaled Aromatherapy on Chemotherapy-induced Nausea and Vomiting: A Systematic Review[J]. J Altern Complement Med,2021,27(12):1058-1069.DOI:10.1089/acm. 2021.0067.
[17] The Joanna Briggs Institute (JBI). Oral Mucositis:Prevention[EB/OL].(2018-01-02)[2021-04-03].http:ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&=jbi&AN=JBI9669.
[18] Chaitanya NC, Muthukrishnan A, Babu DBG, et al.Role of Vitamin E and Vitamin a in Oral Mucositis Induced by Cancer Chemo/Radiotherapy A Meta-analysis[J].J Clin Diagn Res,2017, 11(5):ZE06-ZE09.DOI:10.7860/JCDR/2017/26845.9905.
[19] Edwards, MDietSt A, Santos, et al. Nutritional Interventions for Oral Mucositis: A Systematic Literature Review[J].Nutrition & Dietetics,2021,78(1):101-114.DOI:10.1111/1747-0080.12656.
[20] Co JL, Mejia MB, Que JC, et al.Effectiveness of Honey on Radiation-induced Oral Mucositis, Time to Mucositis, Weight Loss, and Treatment Interruptions Among Patients with Head and Neck Malignancies:A Meta-analysis and Systematic Review of Literature[J]. Head Neck,2016,38(7):1119-28.DOI:10.1002/hed. 24431.
[21] Wei T T, Tian X, Zhang F Y, et al.Music Interventions for Chemotherapy-Induced Nausea and Vomiting:A Systematic Review and Meta-analysis[J]. Support Care Cancer,2020, 28(9):4031-4041.DOI:10.1007/s00520-020-05409-w.
[22] Braud A, Boucher Y.Taste Disorder’s Management: A Systematic Review[J].Clin Oral Investig, 2020,24(6):1889-1908.DOI: 10.1007/s00784-020-03299-0.
[23] 董元鸽,张晓菊,陆箴琦,等.化疗致味觉改变评估及护理的最佳证据总结[J].护理学杂志,2020,35(12):33-37.DOI: 10.3870/j.issn. 1001-4152.2020.12.033.
[24] Spotten LE, Corish CA, Lorton CM, et al.Subjective and objective Taste and Smell Changes in Cancer[J]. Ann Oncol,2017,28(5):969-984.DOI: 10.1093/annonc/mdx018.
[25] 裴露斯,杨雪梅,翟田田,等.冷冻疗法降低化疗患者口腔黏膜炎发生的Meta分析[J].护理学报,2020,27(6):23-28.DOI: 10.16460/j. issn1008-9969.2020.06.023.
[26] Sonis ST, Hashemi S, Epstein JB, et al.Could the Biological Robustness of Low Level Laser Therapy (Photobiomodulation) Impact its Use in the Management of Mucositis in Head and Neck Cancer Patients[J]. Oral Oncol, 2016, 54:7-14.DOI: 10.1016/j.oraloncology. 2016.01.005.
[27] Dranitsaris G, Molassiotis A, Clemons M, et al.The Development of a Prediction Tool to Identify Cancer Patients at High Risk for Chemotherapy-induced Nausea and Vomiting[J]. Ann Oncol, 2017, 28(6):1260-1267.
[28] Farahani MA, Afsargharehbagh R, Marandi F,et al.Effect of Aromatherapy on Cancer Complications:A Systematic Review[J]. Complement Ther Med, 2019,47:102169.DOI: 10.1016/j.ctim.2019.08.003.
[29] 宋嘉婷,黄绮华,肖文莉,等.灸法防治肿瘤患者化疗不良反应的文献计量学分析[J].护理学报,2021,28(15):20-24.DOI: 10.16460/j.issn1008-9969.2021.15.020.
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