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Journal of Nursing ›› 2025, Vol. 32 ›› Issue (1): 1-6.doi: 10.16460/j.issn1008-9969.2025.01.001

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Physical-psychological symptom burden trajectories and influencing factors in nasopharyngeal carcinoma patients during induction chemotherapy plus concurrent chemoradiotherapy

LIU Qi1, LIU Jia-li2a, LIU Yu2a, YANG Li-min3, FAN Yu-ying2b, LV Xing2b, JIN Hui-ying2a   

  1. 1. School of Nursing, Sun Yat-sen University, Guangzhou 510060, China;
    2a. Dept. of Nursing Administration; 2b. Dept. of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou 510060, China;
    3. Dept. of Nursing Administration, Affiliated Hospital of Guizhou Medical University, Guiyang 561113, China
  • Received:2024-08-11 Online:2025-01-10 Published:2025-02-20

Abstract: Objective To identify physical-psychological symptom burden trajectories and influencing factors of nasopharyngeal carcinoma patients during induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT). Methods Nasopharyngeal carcinoma patients who received IC plus CCRT (n=212) in a tertiary grade-A hospital of Guangzhou were selected as research subjects. The Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events were collected during IC, at the 5th, 10th, 15th, 20th, and 25th radiotherapy, at the end of radiotherapy, and one month after radiotherapy. Latent class growth modeling was applied to analyze the trajectoy categories of physical and psychological symptom burden. Results Two physical symptom burden trajectories were identified, labeling “high physical symptom burden group” (89.2%) and “moderate-high physical symptom burden group” (10.8%). Three psychological symptom burden trajectories were identified as “moderate-high psychological symptom burden group” (22.7%), “low psychological symptom burden group” (47.6%), and “no psychological symptom burden group” (29.7%). The symptom burden of the high physical symptom burden group and the medium-high psychological symptom burden group was higher than that of the other groups during IC (P<0.05). Logistic regression analysis showed that age, the presence or absence of other chronic diseases and information acquisition ability were the influencing factors of physical symptom burden trajectories, while information acquisition ability and sense of meaning were the influencing factors of the psychological symptom burden trajectories (P<0.05). Conclusion There is heterogeneity in the trajectories of physical and psychological symptom burden during treatment. Younger patients, and those with other chronic diseases or poor information acquisition ability are more likely to have a sustained high physical symptom burden. Patients with poor information acquisition ability or lower sense of meaning are more likely to have a sustained higher psychological symptom burden.

Key words: nasopharyngeal carcinoma, induction chemotherapy plus concurrent chemoradiotherapy, symptom burden trajectories, latent class growth model, health literacy, sense of coherence

CLC Number: 

  • R473.73
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