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Journal of Nursing ›› 2018, Vol. 25 ›› Issue (22): 38-43.doi: 10.16460/j.issn1008-9969.2018.22.038

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Systematic Review and Meta-analysis of Risk Factors of Post Stroke Delirium

LI Zhena, CAO Jinga, LI Jia-qianb, WU Xin-juana   

  1. a. Dept. of Nursing Administration; b. Dept. of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China
  • Received:2018-07-03 Published:2020-07-08

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Abstract: Objective To conduct a systematic review and meta-analysis of risk factors for post stroke delirium (PSD)and provide reference for effective prevention of PSD. Methods Studies on risk factors for PSD from PubMed, EMbase, CINAHL, Cochrane Library, PsycINFO, CNKI, Wanfang, CBM, VIP before February 2018 were searched. Two reviewers independently assessed the quality of included studies. Data were combined by fixed or random effects models using Stata 14.0. Begg test combined with funnel plot was implemented to evaluate publication bias. Results Fourteen studies were concluded with 4,807 stroke patients, among which 784(16.31%) were diagnosed with delirium. The quality of studies was moderate or high. A total of 8 risk factors were involved. The OR for these factors was vision deficits 31.76 (95%CI:11.61~86.86), increased C-reactive protein 7.64 (95%CI:1.83~31.90), cognitive decline 7.48 (95%CI：3.63~15.42), anterior circulation infarction 5.24 (95%CI:2.89~9.49), hemorrhagic stroke3.70(95%CI:3.64~3.77), infection 3.67 (95%CI:2.19~6.16), stroke severity 1.23 (95%CI:1.06~1.42), and age 1.07 (95%CI:1.02~1.13) resepetively. Publish bias existed in anterior circulation infarction. Conclusion Vision deficits, increased C-reactive protein, cognitive decline, hemorrhagic stroke, infection, stroke severity and age are risk factors for PSD. Evidences are not sufficient for the impact of anterior circulation infarction on PSD. Early intervention for these modifiable risk factors is recommended.

Key words: stroke, delirium, risk factor, systematic review, Meta-analysis

CLC Number: 

  • R248.2
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