Abstract: Objective To discuss the influence of grip strength on hemodynamics of upper limb veins after the implantation of PICC in patients with tumors and to provide scientific basis for the exercise of holding the ball. Methods We conducted prospective clinical observation and 40 patients with PICC catheter implanted in a tertiary grade A hospital in Beijing from July to August 2018 were selected. Patients performed with gripper to measure grip strength by self contrast method, and the effects of grip force on venous vessel diameter, blood flow velocity and blood pressure were observed by ultrasound. Results In rest state, the vessel diameter of venous blood flow was (4.18±0.83) mm; the peak velocity was(12.39±3.17) cm/s and the pressure of vein to vessel wall was(0.06±0.03) mmHg. There was no significant difference in vessel diameter with different grip strength (P>0.05) but there was in peak velocity and pressure of blood flow (P<0.05). The changes of venous hemodynamics with different grip strength were statistically significant. The peak velocity and pressure of venous blood flow after using 80% maximum grip strength (MGS), 90% MGS and 100% MGS were significantly different from those in rest state (P<0.05). Conclusion Gripping force can effectively increase venous blood flow velocity and venous pressure on the vascular wall, but it does not cause discomfort to patients. It can be used to guide clinical patients with PICC for functional exercise. The pressure of 80% MGS-100% MGS is the most suitable grip strength, which can be promoted in clinical practice.

Key words: tumor patient, PICC, grip strength, hemodynamics, clinical research