Abstract: Objective To explore the incidence and risk factors of hypoglycemia in patients with hepatocellular carcinoma (HCC). Methods We collected and analyzed the clinical data of 232 patients with HCC in our cancer center from April 2020 to June 2021. Multivariate logistic regression analysis was performed to identify the risk factors associated with hypoglycemia. Results The incidence of hypoglycemia in patients with HCC was 28.9% (67/232). Child-Pugh grade C and alpha-fetoprotein (AFP) level were the influencing factors for hypoglycemia in patients with HCC, and the glycated hemoglobin (HbA1c) was a protective factor. Compared with patients with Child-Pugh class A, the OR of hypoglycemia in class C patients increased by 8.050 times; for every 1% increase in glycosylated hemoglobin in patients with hepatocellular carcinoma, the risk of hypoglycemia decreased by 0.496 times. Conclusion Child-Pugh stage and HbA1c are associated with hypoglycemia in patients with HCC. Our study suggests that these factors should be comprehensively considered when estimating the risk of hypoglycemia in these patients, and the diagnosis, treatment, and nursing plan should be adjusted in time to reduce the incidence of hypoglycemia.

Key words: hepatocellular carcinoma, hypoglycemia, Child-Pugh stage, glycated hemoglobin, risk factor