Construction and verification of risk prediction model for hypoglycemia with hepatocellular carcinoma

ZHENG Xiao-jing; YAN Hong-hong; LI Hui-jing; CHEN Si-juan; CHEN Xiu-mei

doi:10.16460/j.issn1008-9969.2025.04.053

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Journal of Nursing ›› 2025, Vol. 32 ›› Issue (4) : 53-58. DOI: 10.16460/j.issn1008-9969.2025.04.053

Construction and verification of risk prediction model for hypoglycemia with hepatocellular carcinoma

ZHENG Xiao-jing, YAN Hong-hong, LI Hui-jing, CHEN Si-juan, CHEN Xiu-mei

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Abstract

Objective To construct and validate a hypoglycemia risk prediction model in patients with primary hepatocellular carcinoma(HCC). Methods A total of 232 patients with primary HCC from April 2020 to June 2021 were involved and divided into hypoglycemia group (n=67) and non-hypoglycemia group (n=165) according to the occurrence of hypoglycemia. The risk factors were retrospectively analyzed and risk prediction model was established. ROC curve was used to verify the efficacy of the prediction model. Results The analysis revealed that Child-Pugh grade C (OR=9.050,95%CI 2.911-28.130, P<0.001) was a risk factor for hypoglycemia in patients with HCC; but glycated hemoglobin (OR=0.504,95%CI 0.325-0.780, P=0.002) was a protective factor. The regression model was: Y=2.317+0.056 Child-Pugh stage (B) + 2.203 Child-Pugh stage (C) -0.686 HbA1c; The area of the ROC curve was 0.737 (95%CI 0.660-0.814), with a sensitivity of 53.7% and specificity of 87.3%. Model validation showed that the area of the ROC curve was 0.827 (95%CI 0.727-0.927), with a sensitivity of 55% and specificity of 81.8%, which suggests good prediction efficacy of the model. Conclusion The hypoglycemia risk prediction model in patients with HCC can help identify population with high risk of hypoglycemia and provide scientific basis for prospective nursing intervention for medical staff.

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hepatocellular carcinoma / hypoglycemia / risk prediction model

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ZHENG Xiao-jing, YAN Hong-hong, LI Hui-jing, CHEN Si-juan, CHEN Xiu-mei. Construction and verification of risk prediction model for hypoglycemia with hepatocellular carcinoma[J]. Journal of Nursing. 2025, 32(4): 53-58 https://doi.org/10.16460/j.issn1008-9969.2025.04.053

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