Abstract: Objective To explore the prevalence of anxiety and depression in female patients undergoing artificial insemination with donor sperm (AID) on the filing day and analyze its influence factors. Methods A convenience sampling was used to select 525 female patients undergoing AID who were treated in Reproductive Center of Guangdong provincial Fertility Hospital from January 2020 to May 2021. A questionnaire survey was conducted with a self-designed general information questionnaire, Self-rating Anxiety Scale(SAS), Self-rating Depression(SDS) and Social Support Rating Scale (SSRS) on the filing day. Multiple linear regression was used to analyze its influencing factors. Results The incidence of anxiety was 21.4% and the standard total score of anxiety 41.20±8.52, while the incidence of depression was 28.2% the standard total score of anxiety 43.66±12.88. Multivariate regression analysis showed that annual family income and social support were main influencing factors of anxiety and depression(P<0.05). Conclusion There are different degrees of anxiety and depression on filing day of female patients undergoing AID and it is recommended that medical staff focus on patients with low annual family income and low level of social support, optimize the examination and treatment process, reduce the number of hospital visits and save their expenses; Provide targeted guidance to couples, so that patients feel more care from their families and husbands; Establish a communication group with the same disease, and regularly carry out salon activities to help female patients undergoing AID to obtain support from the group. Thus, relieves their anxiety and depression.

Key words: AID, female patient, mental state, social support