Abstract: Objective To develop a questionnaire of care knowledge-attitude-practice (KAP) of caregivers for children with acute leukemia and to test its reliability and validity. Methods Based on KAP theory, the questionnaire was developed by using literature review,semi-structured interviews,and 2 rounds of expert consultation. The project analysis was carried out using a sample of 360 caregivers for children with acute leukemia from the wards in 2 tertiary grade A hospitals in Zhengzhou. The validity of the questionnaire was analyzed by exploratory factor analysis and content validity. The internal consistency coefficient and bisected reliability were used to evaluate the reliability of the questionnaire. Results Totally 13 items were deleted. The questionnaire was composed of 41 items and 3 dimensions including knowledge (22 items), attitude (11 items), and behavior (8 items). The 3 dimensions included 4, 2 and 1 common factors respectively and they explained 72.141%, 70.336%, 55.798% of the variances respectively by using exploratory factor analysis. The S-CVI was 0.909, 0.922, 0.929 respectively,and I-CVI ranged from 0.857 to 1.000. The Cranach's α of the questionnaire and each dimension was 0.967, 0.953, 0.916 and 0.885 respectively. The split-half reliability of the general questionnaire and each dimension was 0.894, 0.842, 0.762, and 0.833 respectively. Conclusion The questionnaire has good reliability and validity, and it can be used to evaluate the care KAP of caregivers for children with acute leukemia.

Key words: acute leukemia, caregiver, knowledge-attitude-practice, questionnaire development, reliability, validity