Abstract: Objective To investigate the clinical effect of Mizone combined with Heshuang (polyethylene glycol electrolyte powder, SF-PEG) in intestinal preparation for outpatients undergoing colonoscopy. Methods Seventy-six patients undergoing morning colonoscopy were divided into experimental group and control group according to random number table method, with 38 cases in each. Before the colonoscopy, the control group received 2 bags of Heshuang diluted with warm water in 2 hours, while the observation group a combination of Mizone and Heshuang diluted with warm water. The time between the start of medication-taking and the first bowel movement, that between the first and last defecation, adverse reactions during colonoscopy and intestinal cleanliness in the two groups were compared. Results Colonoscopy was completed successfully in both groups. Time from the start of medication-taking to first bowel movement, that between the first and last defecation, and the incidence of adverse reactions in the observation group were significantly shorter and lower than those in the control group(P<0.05). There was no significant difference in the intestinal cleanliness between the two groups (P>0.05). Taste satisfaction rate in the observation group were significantly higher than that in the control group (84% VS 51%), and 92% of the patients in the observation group could finish drinking the laxative, indicating significantly higher medication compliance (P<0.05). Conclusion The combination of Mizone and Heshuang in intestinal preparation during colonoscopy has the advantages of shorter intestinal preparation time, less adverse reactions, and better taste experience and medication compliance.

Key words: Mizone, polyethylene glycol electrolyte powder, Heshuang, colonoscopy, intestinal preparation