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护理学报 ›› 2024, Vol. 31 ›› Issue (18): 35-38.doi: 10.16460/j.issn1008-9969.2024.18.035

• 循证护理 • 上一篇    下一篇

临床研究中基于患者报告结局的缺失值问题及对策

史晨1, 闫泽霖1, 马嘉骏1, 李新旭2, 欧春泉1   

  1. 1.南方医科大学 公共卫生学院生物统计学系,广东 广州 510515;
    2.博济医药科技股份有限公司 博济数据科技（北京）有限公司,北京 100077
  • 收稿日期:2024-06-15 出版日期:2024-09-25 发布日期:2024-10-08
  • 通讯作者: 欧春泉（1974-）,女,湖南宁乡人,博士,教授,博士研究生导师。E-mail: ouchunquan@hotmail.com
  • 作者简介:史晨（1998-）,女,安徽阜阳人,本科学历,博士研究生在读。
  • 基金资助:
    广东省基础与应用基础研究基金（2021A1515220065）

Missing data in patient-reported outcomes in clinical studies and its solutions

SHI Chen1, YAN Ze-lin1, MA Jia-jun1, LI Xin-xu2, OU Chun-quan1   

  1. 1. Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou 510515, China;
    2. Boji Medical Technology Co., Ltd, Boji Data Technology (Beijing) Ltd, Beijing 100077, China
  • Received:2024-06-15 Online:2024-09-25 Published:2024-10-08

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摘要： 目的 整合患者报告结局（patient-reported outcomes, PRO）的缺失值问题及对策,为尽可能降低PRO数据缺失所带来的影响提供解决思路和参考。方法 检索国内外相关文献,从数据缺失的原因及其影响、可行的预防措施、对缺失值的处理及规范报道等几个方面归纳PRO的缺失值问题。结果 对缺失数据产生原因及其严重影响的充分认识,严谨的研究设计,规范的实施流程等可降低PRO数据缺失的风险;对无法避免的缺失数据进行合理处理和分析,并透明报告,也能得出可信的结论。结论 随着科学研究的不断发展,PRO数据应被更合理、更有效地利用。

关键词: 患者报告结局, 缺失值, 量表, 临床研究

Abstract: Objective To explore missing data in patient-reported outcomes (PRO) and the solutions, and to provide references for reducing the impact of missing data in PRO as much as possible. Methods Relevant literatures at home and abroad were searched, and missing data in PRO were summarized from the perspective of causes and influences of data missing, feasible preventive measures, handling of missing data, and standardized reporting. Results Adequate understanding of the causes and serious impacts of missing data, rigorous study design, and standardized implementation procedures can reduce the risk of data missing in PRO. Reasonable processing and analysis of unavoidable missing data and transparent reporting were beneficial to drawing credible conclusions. Conclusion With the continuous development of scientific research, PRO data should be used more rationally and effectively.

Key words: patient-reported outcomes, missing data, scale, clinical study

中图分类号: 

  • R47
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