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Journal of Nursing ›› 2024, Vol. 31 ›› Issue (24): 37-43.doi: 10.16460/j.issn1008-9969.2024.24.037

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Efficacy of different non-drug interventions on cancer-related fatigue in breast cancer patients: a network Meta-analysis

YAO Wan-qing1a, YANG Li-zhuang2, CHEN Dan-dan1b, ZHANG Wan-qiu1b, LU Wei1a, GUAN Cui-hong1a, LI Hai2   

  1. 1a. Smart Rehabilitation Center for Cancer; 1b. Dept. of Nursing Administration, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230088, China;
    2. Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
  • Received:2024-07-08 Online:2024-12-25 Published:2025-01-09

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Abstract: Objective To evaluate and compare the efficacy of different non-drug interventions on cancer-related fatigue in breast cancer patients, and to provide evidence for the formulation of relevant intervention programs. Methods We systematically retrieved randomized controlled trials（RCT）on the effects of non-drug interventions on cancer-related fatigue in breast cancer patients from CNKI, Wanfang Data, VIP, CBM, Medline, PubMed, Web of Science, the Cochrane Library. The retrieval period spanned from the inception to August 2024. Stata14.0 was used for data analysis. Results A total of 38 studies were included,including 12 non-pharmaceutical interventions,involving 3 901 breast cancer patients. The Results showed that compared with conventional care, resistance and high-intensity interval training, aerobic and high-intensity interval exercise, cognitive behavioral therapy, yoga and massage had better effects on cancer-related fatigue in breast cancer patients(P<0.05). The area under the cumulative rank probability map showed that resistance and high-intensity interval training was the best non-drug intervention. Conclusion A combination of resistance exercise and high-intensity interval training is the most effective for alleviating fatigue in breast cancer patients, and it is recommended that clinical nursing prioritize this approach. However, a large number of high-quality RCTs are still needed for the verification.

Key words: breast neoplasm, cancer-related fatigue, non-drug intervention, network Meta-analysis

CLC Number: 

  • R473.73
[1] Sung H, Ferlay J, Siegel RL, et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. DOI: 10.3322/caac.21660.
[2] 刘宗超,李哲轩,张阳,等. 2020全球癌症统计报告解读[J]. 肿瘤综合治疗电子杂志, 2021, 7(2):1-14. DOI:10.12151/JMCM.2021.02-01.
[3] Cao W, Chen HD, Yu YW, et al.Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020[J]. Chin Med J (Engl), 2021, 134(7): 783-791. DOI:10.1097/CM9.0000000000001474.
[4] 韦文棋. 基于语音的乳腺癌患者癌因性疲乏分类模型构建[D]. 长春:吉林大学. 2020. DOI: 10.27162/d.cnki.gjlin.2020.001278.
[5] Fabi A, Bhargava R, Fatigoni S, et al.Cancer-related fatigue: ESMO clinical practice guidelines for diagnosis and treatment[J]. Ann oncol, 2020, 31(6):713-723.DOI:10.1016/j.annonc.2020.02.016.
[6] Armsterong DK, Alvarez RD, Bakkum-gamez JN, et al. Ovarian cancer, version 2.2020, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw, 2021,19(2): 191-226. DOI: 10.6004/jnccn.2021.0007.
[7] 冯宪凌, 白杨, 古钰君. 《儿童、青少年和年轻成人癌症幸存者癌因性疲乏监测》解读[J]. 护理学报, 2022, 29(24): 64-67. DOI:10.16460/j.issn1008-9969.2022.24.064.
[8] 张剑军, 钱建新.中国癌症相关性疲乏临床实践诊疗指南(2021 年版)[J]. 中国癌症杂志. 2021, 31(9):852-872. DOI: 10.19401/j.cnki.1007-3639.2021.09.012.
[9] Hofman M, Ryan JL, Figueroa-moseley CD, et al. Cancer-related fatigue:the scale of the problem[J].Oncologist, 2007, 12(S1): 4-10. DOI: 10.1634/theoncologist.12-S1-4.
[10] Amidi A, Buskbjerg CR, Damholdt MF, et al.Changes in sleep following internet-delivered cognitive-behavioral therapy for insomnia in women treated for breast cancer: a 3-year follow-up assessment[J].Sleep Med, 2022,96(2022): 35-41. DOI: 10.1016/j.sleep.2022.04.020.
[11] Steindorf K, Schmidt ME, Klassen O, et al.Randomized controlled trial of resistance training in breast cancer patients receiving adjuvant radiotherapy: results on cancer-related fatigue and quality of life[J]. Ann Oncol, 2014, 25(11): 2237-2243. DOI: 10.1093/annonc/mdu374.
[12] Zachariae R, Amidi A, Damholdt MF,et al.Internet-delivered cognitive-behavioral therapy for insomnia in breast cancer survivors: a randomized controlled trial[J]. J Natl Cancer Inst,2018,110(8):880-887.DOI:10.1093/jnci/djx293.
[13] 李婧雯, 梅紧紧, 王艺莹, 等.不同针刺方法治疗脑卒中后患者肢体痉挛总有效率的贝叶斯网状 Meta 分析[J]. 护理学报, 2022, 29(3):1-6. DOI: 10.16460/j.issn1008-9969.2022.03.001.
[14] 张青月, 肖珊, 阎玲, 等. 正念减压疗法在乳腺癌患者中应用效果的Meta分析[J]. 护理管理杂志, 2018, 18(11): 761-765. DOI: 10.3969/j.issn.1671-315x.2018.11.001.
[15] 邹凌云, 杨柳, 何晓玲, 等. 有氧运动对乳腺癌患者癌因性疲乏疗效的Meta分析[J]. 中国全科医学, 2014, 17(13): 1524-1528. DOI: 10.3969/j.issn.1007-9572.2014.13.020.
[16] 刘宇, 姜桐桐, 史铁英, 等. 非药物性干预对化疗期病人睡眠质量影响的网状Meta分析[J]. 护理研究, 2020, 34(22): 3965-3971. DOI: 10.12102/j.issn.1009-6493.2020.22.005.
[17] 朱文敏, 魏小龙. 非药物干预方法对乳腺癌患者康复效果的网状Meta分析[J]. 中华护理杂志, 2020,55(6):862-867. DOI: 10.3761/j.issn.0254-1769.2020.06.013.
[18] Higgins J, Green SE.Cochrane handbook for systematic reviews of interventions version 5.1.0[M]. London: Wiley, 2011: 190-202.
[19] Salanti G, Ades AE, Ioannidis JP.Graphical methods and numerical summaries for presenting results from multipletreatment Meta-analysis: an overview and tutorial[J]. J Clin Epidemiol,2011,64(2):163-171.DOI:10.1016/j.jclinepi.2010.03.016.
[20] Schmidt ME, Wiskemann J, Armbrust P, et al.Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: a randomized controlled trial[J]. Int J Cancer,2015,137(2): 471-480. DOI: 10.1002/ijc.29383.
[21] Micheletti S, Serra P, Tese i A, et al. Effects of yoga practice on physiological distress, fatigue and QOL in patients affected by breast cancer undergoing adjuvant radiotherapy[J]. Tech Innov Patient Support Radiat Oncol, 2022, 24(2022): 32-39. DOI: 10.1016/j.tipsro.2022.09.005.
[22] Campbell A, Mutrie N, White F, et al.A pilot study of a supervised group exercise programme as a rehabilitation treatment for women with breast cancer receiving adjuvant treatment[J].Eur J Oncol Nurs, 2005(9):56-63. DOI: 10.1016/j.ejon.2004.03.007.
[23] Mutrie N, Campbell AM, Whyte F, et al.Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomized controlled trial[J]. BMJ, 2007, 334(7592): 517-524. DOI: 10.1136/bmj.39094.648553.AE.
[24] Hwang JH, Chang HJ, Shim YH, et al.Effects of supervised exercise therapy in patients receiving radiotherapy for breast cancer[J]. Yonsei Med J, 2008, 49(3):443-450. DOI: 10.3349/ymj.2008.49.3.443.
[25] 段艳芳, 王海蓉, 许慧娟, 等. 芳香疗法联合穴位按摩缓解乳腺癌术后化疗患者疲乏与睡眠障碍[J].护理学杂志,2022,37(17):50-54. DOI:10.3870/j.issn.1001-4152.2022.17.050.
[26] 曹鑫, 张欢, 刘玲. 正念训练干预对乳腺癌患者化疗后癌因性疲乏的研究[J]. 重庆医学, 2016, 45(21): 2953-2955. DOI: 10.3969/j.issn.1671-8348.2012.21.022.
[27] Ancoli-Israel S, Rissling M, Neikrug A, et al.Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer[J]. Support Care Cancer, 2012, 20(6): 1211-1219. DOI: 10.1007/s00520-011-1203-z.
[28] Ferguson RJ, Sigmon ST, Pritchard AJ, et al.A randomized trial of video conference-delivered cognitive behavioral therapy for survivors of breast cancer with self-reported cognitive dysfunction[J]. Cancer, 2016: 122(11): 1782-1791. DOI: 10.1002/cncr.29891.
[29] 王媛媛. 铺姜灸对乳腺癌化疗患者癌因性疲乏干预效果的临床研究[D]. 广州, 广州中医药大学, 2019.DOI:10.27044/d.cnki.ggzzu.2019.000197.
[30] 章立楠, 邵薇娜, 赵港美, 等. 乳腺癌患者化疗后癌因性疲乏调查和正念训练干预临床价值研究[J]. 中国妇幼保健, 2021, 36(16):3778-3782. DOI:10.19829/j.zgfybj.issn.1001-4411.2021.16.038.
[31] Bolam KA, Mijwel S, Rundqvis H, et al.Two-year follow-up of the OptiTrain randomised controlled exercise trial[J]. Breast Cancer Res Treat, 2019, 175(3):637-648. DOI: 10.1007/s10549-019-05204-0.
[32] 沈傲梅, 强万敏, 王晴, 等. 网络正念癌症康复对过渡期乳腺癌生存者知觉压力、疲乏及焦虑的影响[J].护士进修杂志, 2021, 36(23): 2113-2123. DOI: 10.16821/j.cnki.hsjx.2021.23.001.
[33] Kiecolt-Glaser JK, Bennett JM, Andridge R, et al.Yoga's Impact on Inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial[J]. J Clin Oncol, 2014, 32(10): 1040-1049.DOI:10.1200/JCO.2013.51.8860.
[34] Chandwani KD, Perkins G, Nagendra HR, et al.Randomized controlled trial of yoga in women with breast cancer undergoing radiotherapy[J]. J Clin Oncol, 2014, 32(10):1058-1065. DOI: 10.1200/JCO.2012.48.2752.
[35] Mostafaei F, Azizi M, Jalali A, et al.Effect of exercise on depression and fatigue in breast cancer women undergoing chemotherapy: a randomized controlled trial[J]. Heliyon, 2021, 7(7): e07657-e07663. DOI: 10.1016/j.heliyon.2021.
[36] Jeste N, Liu LQ, Rissling M, et al.Prevention of quality-of-life deterioration with light therapy is associated with changes in fatigue in women with breast cancer undergoing chemotherapy[J]. Qual Life Res, 2013,22(6): 1239-1244. DOI: 10.1007/s11136-012-0243-2.
[37] Jong MC, Boers I, Schouten van der Velden AP, et al. A randomized study of yoga for fatigue and quality of life in women with breast cancer undergoing(Neo) adjuvant chemotherapy[J].J Altern Complement Med, 2018, 24(9-10): 942-953. DOI: 10.1089/acm.2018.0191.
[38] Taso CJ, Lin HS, Lin WL, et al.The Effect of yoga exercise on improving depression, anxiety, and fatigue in women with breast cancer: a randomized controlled trial[J].J Nurs Res,2014,22(3):155-163.DOI:10.1097/jnr. 0000000000000044.
[39] Bower JE, Garet D, Sternlieb B, et al.Yoga for persistent fatigue in breast cancer survivors[J]. Cancer, 2012, 118(15): 3766-3775. DOI: 10.1002/cncr.26702.
[40] Mijwel S, Backman M, Bolam KA, et al.Adding high intensity interval training to conventional training modalities: optimizing health related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial[J]. Breast Cancer Res Treat, 2018,168(1):79-93.DOI:10.1007/s10549-017-4571-3.
[41] Mijwel S, Jervaeus A, Bolam1 KA,et al. High-intensity exercise during chemotherapy induces beneficial effects 12 months into breast cancer survivorship[J]. J Cancer Surviv, 2019,13(2): 244-256. DOI: 10.1007/s11764-019-00747-z.
[42] 俎浩杰. 弹力带锻炼对乳腺癌患者的癌因性疲劳、睡眠质量的影响[D]. 杭州, 浙江师范大学, 2021. DOI: 10.27464/d. cnki. gzsfu. 2021. 000200.
[43] Courneya KS, Segal RJ, Mackey JR, et al.Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial[J]. J Clin Oncol, 2007, 25(28): 4396-4404. DOI: 10.1200/JCO.2006.08.2024.
[44] Kinkead B, Schettle PJ, Larson ER, etal. Massage therapy decreases cancer-related fatigue: results from a randomized early phase trial[J]. Cancer, 2018, 124(3): 546-554. DOI: 10.1002/cncr.31064.
[45] 陈军, 方乃青, 王蕾, 等. 针刺治疗乳腺癌患者癌因性疲乏30例临床研究[J]. 江苏中医药, 2016, 48(12):56-58.
[46] 周猜. 针刺原穴治疗乳腺癌患者癌因性疲乏的临床观察[D]. 广州, 广州中医药大学, 2018.
[47] 马丽. 铺灸治疗乳腺癌癌因性疲乏的临床观察[D]. 合肥, 安徽中医药大学, 2020.
[48] 耿雨晴, 尤建良, 龚时夏, 等. 雷火灸治疗乳腺癌化疗患者气虚型癌因性疲乏的效果和安全性观察[J]. 中医临床研究, 2020,12(22):33-35. DOI:10.3969/j.issn.1674-7860.2020.20.010.
[49] 林云月, 林朝春, 陈隐, 等. 艾灸疗法联合常规护理治疗乳腺癌化疗后癌因性疲乏30例[J]. 福建中医药, 2023, 54(10): 67-69.DOI: 10.13260/j.cnki.jfjtcm.2023.10021.
[50] 王国妃, 王曙红, 姜萍岚, 等. 瑜伽对乳腺癌化疗患者癌因性疲乏的干预效果[J]. 中南大学学报(医学版), 2014, 39(10):1077-1082. DOI:10.11817/j.issn.1672-7347.2014.10.016
[51] 王坤, 陈长英, 艾建赛, 等. 正念减压疗法对乳腺癌患者化疗期间疲乏及睡眠质量的影响[J].中华护理杂志, 2017, 52(5): 518-523. DOI:10.3761/j.issn.0254-1769.2017.05.001.
[52] Lengacher CA, Reich RR, Paterson CL,et al.Examination of broad symptom improvement resulting from mindfulness-based stress reduction in breast cancer survivors: a randomized controlled trial[J]. J Clin Oncol, 2016, 34(24): 2827-2834. DOI: 10.1200/JCO.2015.65.7874.
[53] 薛晓燕, 尉晓芳, 郭晋. 认知行为疗法对乳腺癌放疗患者癌性疲劳与生活质量的影响[J]. 沈阳医学院学报, 2015, 17(2):74-77.DOI:10.3969 /j.issn.1008-2344.2015.02.003.
[54] Abrahams HJG, Gielissen MFM, Donders RRT, et al.The efficacy of Internet-based cognitive behavioral therapy for severely fatigued survivors of breast cancer compared with care as usual: a randomized controlled trial[J]. Cancer, 2017, 123(19): 3825-3834. DOI: 10.1002/cncr.30815.
[55] Mustian KM, Alfano CM, Heckler C, et al.Comparison of pharmaceutica psychological and exercise treatments for cancer-related fatigue:a Meta -analysis[J]. JAMA Oncol, 2017, 3(7):961-968. DOI:10.1001/jamaoncol.2016.6914.
[56] 蹇秋枫, 姚倩, 周媛媛. 瑜伽对乳腺癌患者癌因性疲乏影响的Meta分析[J]. 护理实践与研究, 2022,19(18): 2784-2793. DOI:10.3969/j.issn.1672-9676.2022.18.022.
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