Symptom clusters in colorectal cancer patients undergoing chemotherapy: a scoping review

WANG Fangying; WU Wanying; YU Jingxuan

doi:10.16460/j.issn2097-6569.2025.12.043

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Journal of Nursing ›› 2025, Vol. 32 ›› Issue (12) : 43-48. DOI: 10.16460/j.issn2097-6569.2025.12.043

Symptom clusters in colorectal cancer patients undergoing chemotherapy: a scoping review

WANG Fangying¹, WU Wanying², YU Jingxuan³

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Abstract

Objective To conduct a scoping review on literature on symptom clusters in colorectal cancer patients undergoing chemotherapy, and to provide reference for the investigation and management of symptom clusters. Methods Scoping review was performed in this study. A systematic search in Chinese and English databases was conducted to collect studies on symptom clusters during chemotherapy for colorectal cancer, with a retrieval time spanning from the inception to June 30, 2024. Results Thirteen studies were collected, identifying 12 distinct symptom clusters. The most frequently reported clusters were digestive symptom clusters, peripheral nerve symptom clusters, fatigue symptom clusters and psychological symptom clusters. There were differences in assessment tools and analysis methods of symptom clusters, and the symptom composition within clusters showing instability. Symptom clusters were observed to fluctuate dynamically throughout chemotherapy, underscoring the need to consider their stage-specific characteristics. Conclusion Standardized multidimensional assessment tools needs to be developed in the future, and multiple statistical methods should be considered to analyze symptom clusters and explore their correlations with biomarkers. Furthermore, it is necessary to conduct multidimensional and longitudinal studies at multiple time points to enhance the universality and credibility of the results, thus providing a basis for precise intervention measures.

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colorectal cancer / chemotherapy / symptom clusters / scoping review

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WANG Fangying, WU Wanying, YU Jingxuan. Symptom clusters in colorectal cancer patients undergoing chemotherapy: a scoping review[J]. Journal of Nursing. 2025, 32(12): 43-48 https://doi.org/10.16460/j.issn2097-6569.2025.12.043

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