Current status of fertility distress in male reproductive-age lymphoma patients and its influencing factors

YU Menghua; WEI Qingfeng; ZHU Longshuang; TANG Yidan; WANG Zhuo; WANG Xinrui

doi:10.16460/j.issn2097-6569.2025.10.007

PDF(866 KB)

Journal of Nursing ›› 2025, Vol. 32 ›› Issue (10) : 7-11. DOI: 10.16460/j.issn2097-6569.2025.10.007

Current status of fertility distress in male reproductive-age lymphoma patients and its influencing factors

YU Menghua^1,2, WEI Qingfeng², ZHU Longshuang¹, TANG Yidan¹, WANG Zhuo¹, WANG Xinrui¹

Author information +

History +

Abstract

Objective To investigate the current status of fertility distress in male lymphoma patients of reproductive age and analyze its influencing factors. Methods Using convenient sampling, 204 male lymphoma patients of reproductive age who visited a hospital in Nanchang City, Jiangxi Province from April to September 2023 were selected as the objects. The General Information Questionnaire, the Reproductive Concern after Cancer Male (RCAC-M), and the Distress Disclosure Index (DDI) were used to conduct the investigation. The influencing factors of fertility distress were analyzed by multiple linear regression analysis. Results The average score of fertility distress among 204 male lymphoma patients of reproductive age was 49.92±12.66, and the score of distress disclosure index was 35.18±12.66. The fertility concerns negatively correlated distress disclosure index (r=-0.529, P<0.001). Age, education background, fertility intention, fertility history, and degree of distress disclosure were important influencing factors for reproductive concerns (P<0.05 for all), accounting for 43.2% of the total variance. Conclusion The level of reproductive concerns of male lymphoma patients of reproductive age is at a moderate to high level. Medical workers should focus on patients being young, highly educated, without bearing a child, with fertility intention and low ability of pain disclosure. Timely oncofertility-related education and psychological support should be considered to improve the self-disclosure ability of male lymphoma patients of reproductive age, so as to alleviate their reproductive concerns.

Key words

lymphoma / reproductive concerns / reproductive age / distress disclosure

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

YU Menghua, WEI Qingfeng, ZHU Longshuang, TANG Yidan, WANG Zhuo, WANG Xinrui. Current status of fertility distress in male reproductive-age lymphoma patients and its influencing factors[J]. Journal of Nursing. 2025, 32(10): 7-11 https://doi.org/10.16460/j.issn2097-6569.2025.10.007

References

[1] Sung H, Ferlay J, Siegel RL, et al.Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021,71(3):209-249.DOI:10.3322/caac.21660.
[2] 武文韬,李达宁,郑帅,等. 1990—2019年中国霍奇金淋巴瘤流行趋势和疾病负担分析[J]. 医学新知, 2021, 31(6): 433-440.DOI: 10.12173/j.issn.1004-5511.202108029.
[3] Yasmin E, Mitchell R, Lane S.Preservation of fertility in teenagers and young adults treated for haematological malignancies[J]. Lancet Haematol,2021,8(2):e149-e160.DOI:10.1016/S2352-3026(20)30324-0.
[4] Kenney LB, Antal Z, Ginsberg JP, et al.Improving male reproductive health after childhood, adolescent, and young adult cancer: progress and future directions for survivorship research[J]. J Clin Oncol,2018,36(21):2160-2168.DOI:10.1200/JCO.2017.76.3839.
[5] Ussher JM, Perz J.Threat of biographical disruption: the gendered construction and experience of infertility following cancer for women and men[J]. BMC Cancer, 2018, 18(1):250.DOI:10.1186/s12885-018-4172-5.
[6] Twitchell DK, Wittmann DA, Hotaling JM, et al.Psychological impacts of male sexual dysfunction in pelvic cancer survivorship[J]. Sex Med Rev,2019,7(4):614-626.DOI:10.1016/j.sxmr.2019.02.003.
[7] 朱飞, 路潜, 刘春蕾, 等. 癌症患者生育忧虑概念分析[J]. 医学研究与教育, 2021, 38(5):51-58.DOI:10.3969/j.issn.1674-490X.2021.05.008.
[8] 任海玲, 焦娜娜, 赵岳. 育龄期乳腺癌患者生育忧虑现状及影响因素研究[J]. 中国护理管理, 2022,22(03):359-363.DOI:10.3969/j.issn.1672-1756.2022.03.008.
[9] 汪丹丹, 张苇, 郑蔚, 等. 生育咨询及教育干预对年轻妇科恶性肿瘤患者生育忧虑的影响[J]. 护理学杂志, 2020,35(18):4-7.DOI:10.3870/j.issn.1001-4152.202018.004.
[10] 吴爽, 叶雅雯, 张彬, 等. 青年女性甲状腺癌患者生育忧虑现状及影响因素分析[J]. 护理学杂志, 2019,34(7):65-68. DOI:10.3870/j.issn.1001-4152.2019.07.065.
[11] Drizin JH, Whitcomb BW, Hsieh TC, et al.Higher reproductive concerns associated with fertility consultation: a cross-sectional study of young adult male cancer survivors[J]. Support Care Cancer, 2021, 29(2):741-750.DOI:10.1007/s00520-020-05527-5.
[12] WHO.WHO recommendations on adolescent sexual and reproductive health and rights: world Health Organization[2018][EB/OL].(2018-10-10)[2023-02-10].http://www.who.int/publications-detial-redirect/9789241514606.
[13] 中华人民共和国卫生部.人类精子库管理办法[S].2001.
[14] Gorman JR, Drizin JH, Malcarne VL, et al.Measuring the multidimensional reproductive concerns of young adult male cancer survivors[J]. J Adolescent Young Adult Oncol, 2020, 9(6):613-620. DOI:10.1089/jayao.2019.0146.
[15] 刘洁, 陶莉, 顾静, 等. 育龄期男性癌后生育忧虑量表的汉化及信效度研究[J]. 护理学杂志, 2023,38(3):86-89.DOI:10.3870/j.issn.1001-4152.2023.03.086.
[16] 李新民. 大学生成人依恋、自我表露与抑郁状态的关系研究[D]. 石家庄:河北师范大学, 2009.DOI: 10.7666/d.y1643374.
[17] Ljungman L, Eriksson LE, Flynn KE, et al.Sexual dysfunction and reproductive concerns in young men diagnosed with testicular cancer: an observational study[J]. J Sex Med, 2019,16(7):1049-1059.DOI:10.1016/j.jsxm.2019.05.005.
[18] Wettergren L, Ljungman L, Micaux OC, et al.Sexual dysfunction and fertility-related distress in young adults with cancer over 5 years following diagnosis: study protocol of the Fex-Can Cohort study[J]. BMC Cancer, 2020,20(1):722.DOI:10.1186/s12885-020-07175-8.
[19] Logan S, Perz J, Ussher JM, et al.Systematic review of fertility-related psychological distress in cancer patients: Informing on an improved model of care[J]. Psychooncology, 2019,28(1):22-30.DOI:10.1002/pon.4927.
[20] Oktay K, Harvey BE, Partridge AH, et al.Fertility preservation in patients with cancer:ASCO clinical practice guideline update[J]. J Clin Oncol, 2018,36(19):1994-2001.DOI: 10.1200/JCO.2018.78.1914.
[21] Baek SY, Lee KH, Kim SB, et al.Knowledge, attitudes, and behaviors toward fertilitypreservation in patients with breast cancer: a cross-sectional survey of physicians[J]. Front Oncol,2023,13:1109694.DOI:10.3389/fonc.2023.1109694.
[22] Anderson RA, Mitchell RT, Kelsey TW, et al.Cancer treatment and gonadal function:experimental and established strategies for fertility preservation in children and young adults[J].Lancet Diabetes Endocrinol,2015,3(7):556-567.DOI:10.1016/S2213-8587(15)00039-X.
[23] 张会敏,孙晓晨,马红梅.年轻癌症患者生育忧虑心理体验质性研究的Meta整合[J].护理学报,2022,29(2):51-56.DOI:10.16460/j.issn1008-9969.2022.02.051.
[24] 钱湛, 杨晓婷, 林觐民. 癌症患者生育忧虑体验的Meta整合[J]. 护理学报, 2023,30(4):55-60.DOI:10.16460/j.issn1008-9969.2023.04.055.
[25] Kahn JH, Hucke BE, Bradley AM, et al.The Distress Disclosure Index:a researchreviewand multitrait-multimethod examination[J]. J Couns Psychol, 2012,59(1):134-149.DOI:10.1037/a0025716.