护理学报 ›› 2025, Vol. 32 ›› Issue (4): 41-47.doi: 10.16460/j.issn1008-9969.2025.04.041
张静1a,2, 彭焕椽1b, 陈佳1b, 鲁永锦1b, 刘克玄1a, 侯晓敏1b
摘要: 目的 检索、评价并整合预防体外循环心脏手术患者手术部位感染的最佳证据,为临床医护人员预防手术部位感染提供可靠的循证依据。方法 运用循证护理方法,按照“6 S”模型检索相关文献,包括临床决策、指南、专家共识、系统评价/Meta分析、证据总结,检索时限建库至2024年4月30日。由2名研究者独立对纳入的文献进行质量评价、证据分级与汇总。结果 该研究共纳入25篇文献,包括5篇临床决策,11篇指南、3篇专家共识、6篇系统评价,从术前、术中、术后3个方面凝练出13个证据主题,术前患者准备、病情优化、皮肤准备、定植菌去除;术中手术室和人员管理、皮肤消毒、预防性抗生素、局部用物、体温管理、胸骨闭合;术后伤口管理、及时拔管、左心辅助装置泵缆线护理。结论 本研究总结了国内外关于成人体外循环心脏手术患者手术部位感染预防的最佳证据,可为医护人员开展循证实践提供依据,更好地指导临床。
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[1] Seidelman JL, Mantyh CR, Anderson DJ.Surgical site infection prevention: a review[J]. JAMA, 2023, 329(3):244-252. DOI: 10.1001/jama.2022.24075. [2] Lin J, Peng Y, Guo L, et al.The incidence of surgical site infections in China[J]. J Hosp Infect, 2024, 146:206-223. DOI: 10.1016/j.jhin.2023.06.004. [3] Dencker EE, Bonde A, Troelsen A, et al.Postoperative complications: an observational study of trends in the United States from 2012 to 2018[J]. BMC Surg, 2021, 21(1):393. DOI: 10.1186/s12893-021-01392-z. [4] Seidelman JL, Baker AW, Lewis SS, et al.Surgical site infection trends in community hospitals from 2013 to 2018[J]. Infect Control Hosp Epidemiol, 2023, 44(4):610-615. DOI: 10.1017/ice.2022.135. [5] 郝星. 2022年中国心血管外科手术和体外循环数据白皮书[J]. 中国体外循环杂志, 2023, 21(4):197-200. DOI: 10.13498/j.cnki.chin.j.ecc.2023.04.2. [6] Grasselli G, Scaravilli V, Alagna L, et al.Gastrointestinal colonization with multidrug-resistant Gram-negative bacteria during extracorporeal membrane oxygenation: effect on the risk of subsequent infections and impact on patient outcome[J]. Ann Intensive Care, 2019, 9(1):141. DOI: 10.1186/s13613-019-0615-7. [7] Massart N, Mansour A, Ross JT, et al. Mortality due to hospital-acquired infection after cardiac surgery[J]. J Thorac Cardiovasc Surg, 2022, 163(6):2131-2140.e3. DOI: 10.1016/j.jtcvs.2020.08.094. [8] WHO. Global guidelines for the prevention of surgical site infection[M]. Geneva: WHO Guidelines Review Committee, 2018. [9] NICE. Surgical site infections: prevention and treatment[M]. London: National Institute for Health and Care Excellence (NICE), 2020. [10] Berríos-Torres SI, Umscheid CA, Bratzler DW, et al.Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017[J]. JAMA Surg, 2017, 152(8):784-791. DOI: 10.1001/jamasurg.2017.0904. [11] Wang Q, Cao M, Tao H, et al.Evidence-based guideline for the prevention and management of perioperative infection[J]. J Evid Based Med, 2023, 16(1):50-67. DOI: 10.1111/jebm.12514. [12] Lazar HL, Salm TV, Engelman R, et al.Prevention and management of sternal wound infections[J]. J Thorac Cardiovasc Surg, 2016, 152(4):962-972. DOI: 10.1016/j.jtcvs.2016.01.060. [13] Abu-Omar Y, Kocher GJ, Bosco P, et al.European Association for Cardio-Thoracic Surgery expert consensus statement on the prevention and management of mediastinitis[J]. Eur J Cardiothorac Surg, 2017, 51(1):10-29. DOI: 10.1093/ejcts/ezw326. [14] 朱政, 胡雁, 邢唯杰, 等. 不同类型循证问题的构成[J]. 护士进修杂志, 2017, 32(21):1991-1994. DOI: 10.16821/j.cnki.hsjx.2017.21.025. [15] Murad MH, Asi N, Alsawas M, et al.New evidence pyramid[J]. Evid Based Med, 2016, 21(4):125-127. DOI: 10.1136/ebmed-2016-110401. [16] 周芬, 郝玉芳, 丛雪, 等. 指南研究与评价工具AGREE Ⅱ及各领域分值的补充解释及思考[J]. 护理学报, 2018, 25(18):56-58. DOI:10.16460/j.issn1008-9969.2018.18.056. [17] The Joanna Briggs Institute. JBI critical appraisal tools[EB/OL].[2024-05-22].https://jbi.global/critical-appraisal-tools. [18] 王春青, 胡雁. JBI证据预分级及证据推荐级别系统(2014版)[J]. 护士进修杂志, 2015, 30(11):964-967. DOI: 10.16821/j.cnki.hsjx.2015.11.002. [19] 张玉洁, 李晓瑾, 吴金艳, 等. JBI循证卫生保健中心证据总结制作流程解读[J]. 护理学报, 2024, 31(16):39-43. DOI: 10.16460/j.issn1008-9969.2024.16.039. [20] Cheung AT, Stafford-Smith M, Bozikis M. Management of cardiopulmonary bypass[EB/OL]. (2023-12-05)[2024-04-30].https://www.uptodate.cn/contents/zh-Hans/management-of-cardiopulmonary-bypass?search=cardiopulmonary+bypass&source=search_result&selectedTitle=2%7E150&usage_type=default&display_rank=2. [21] Anderson DJ, Sexton DJ. Overview of control measures for prevention of surgical site infection in adults[EB/OL]. (2024-02-27)[2024-04-30]. https://www.uptodate.cn/contents/zh-Hans/overview-of-control-measures-for-prevention-of-surgical-site-infection-in-adults?search=%E6%A6%82%E8%BF%B0%E9%A2%84%E9%98%B2%E6%88%90%E4%BA%BA%E6%89%8B%E6%9C%AF%E9%83%A8%E4%BD%8D%E6%84%9F%E6%9F%93%E7%9A%84%E6%8E%A7%E5%88%B6%E6%8E%AA%E6%96%BD&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1. [22] Anderson DJ. Antimicrobial prophylaxis for prevention of surgical site infection in adults[EB/OL].(2022-10-18)[2024-04-30]. https://www.uptodate.cn/contents/zh-Hans/antimicrobial-prophylaxis-for-prevention-of-surgical-site-infection-in-adults?search=%E6%88%90%E4%BA%BA%E6%89%8B%E6%9C%AF%E9%83%A8%E4%BD%8D%E6%84%9F%E6%9F%93%E7%9A%84%E6%8A%97%E7%94%9F%E7%B4%A0%E9%A2%84%E9%98%B2&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1#H13. [23] Sexton DJ, Smith BA. Postoperative mediastinitis after cardiac surgery[EB/OL]. (2022-11-21)[2024-04-30]. https://www.uptodate.cn/contents/zh-Hans/postoperative-mediastinitis-after-cardiac-surgery?search=cardiac+surgery&source=search_result&selectedTitle=10%7E150&usage_type=default&display_rank=10. [24] Orgill DP. Surgical management of sternal wound complications[EB/OL]. (2023-11-14)[2024-04-30]. https://www.uptodate.cn/contents/zh-Hans/surgical-management-of-sternal-wound-complications?search=surgical+site+infection&source=search_result&selectedTitle=30%7E150&usage_type=default&display_rank=30. [25] Ban KA, Minei JP, Laronga C, et al.American College of Surgeons and Surgical Infection Society: surgical site infection guidelines, 2016 update[J]. J Am Coll Surg, 2017, 224(1):59-74. DOI: 10.1016/j.jamcollsurg.2016.10.029. [26] Bashaw MA, Keister KJ.Perioperative strategies for surgical site infection prevention[J]. AORN J, 2019, 109(1):68-78. DOI: 10.1002/aorn.12451. [27] Ling ML,Apisarnthanarak A,Abbas A,et al.APSIC guidelines for the prevention of surgical site infections[J]. Antimicrob Resist Infect Control, 2019, 8:174. DOI: 10.1186/s13756-019-0638-8. [28] Calderwood MS,Anderson DJ, Bratzler DW, et al.Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update[J]. Infect Control Hosp Epidemiol, 2023, 44(5):695-720. DOI: 10.1017/ice.2023.67. [29] Mertes PM, Kindo M, Amour J, et al.Guidelines on enhanced recovery after cardiac surgery under cardiopulmonary bypass or off-pump[J]. Anaesth Crit Care Pain Med, 2022, 41(3):101059. DOI: 10.1016/j.accpm.2022.101059. [30] Wahba A, Milojevic M, Boer C, et al.2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery[J]. Eur J Cardiothorac Surg, 2020, 57(2):210-251. DOI: 10.1093/ejcts/ezz267. [31] Grant MC, Crisafi C, Alvarez A, et al.Perioperative care in cardiac surgery: a joint consensus statement by the Enhanced Recovery After Surgery(ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS)[J]. Ann Thorac Surg, 2024, 117(4):669-689. DOI: 10.1016/j.athoracsur.2023.12.006. [32] Bouza E, de Alarcón A, Fariñas MC, et al. Prevention, diagnosis and management of post-surgical mediastinitis in adults consensus guidelines of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Research Centre Network for Respiratory Diseases (CIBERES)[J]. J Clin Med, 2021, 10(23):5566. DOI: 10.3390/jcm10235566. [33] Wei J, He L, Weng F, et al.Effectiveness of chlorhexidine in preventing infections among patients undergoing cardiac surgeries: a Meta-analysis and systematic review[J]. Antimicrob Resist Infect Control, 2021, 10(1):140. DOI: 10.1186/s13756-021-01009-3. [34] Yao D, Feng G, Zhao F, et al.Effects of platelet-rich plasma on the healing of sternal wounds: a Meta-analysis[J]. Wound Repair Regen, 2021, 29(1):153-167. DOI: 10.1111/wrr.12874. [35] Fiocco A, Dini M, Lorenzoni G, et al.The prophylactic use of negative-pressure wound therapy after cardiac surgery: a Meta-analysis[J]. J Hosp Infect, 2024, 148:95-104. DOI: 10.1016/j.jhin.2024.04.003. [36] Caldonazo T, Dell’Aquila M, Cancelli G, et al. Thorax support vest to prevent sternal wound infections in cardiac surgery patients-a systematic review and Meta-analysis[J]. Interdiscip Cardiovasc Thorac Surg, 2024, 38(4):ivae055. DOI: 10.1093/icvts/ivae055. [37] Tam DY, Nedadur R, Yu M, et al.Rigid plate fixation versus wire cerclage for sternotomy after cardiac surgery: a Meta-analysis[J]. Ann Thorac Surg, 2018, 106(1):298-304. DOI: 10.1016/j.athoracsur.2018.02.043. [38] Koken ZO, Yalcin YC, van Netten D, et al. Driveline exit-site care protocols in patients with left ventricular assist devices: a systematic review[J]. Eur J Cardiothorac Surg, 2021, 60(3):506-515. DOI: 10.1093/ejcts/ezab195. [39] Thomsen T, Villebro N, Møller AM. Interventions for preoperative smoking cessation[J].Cochrane Database Syst Rev, 2014,2014(3):CD002294.DOI:10.1002/14651858.CD002294.pub4. [40] Webster J, Osborne S. Preoperative bathing or showering with skin antiseptics to prevent surgical site infection[J]. Cochrane Database Syst Rev,2015,2015(2):CD004985. DOI: 10.1002/14651858.CD004985.pub5. [41] Tanner J, Melen K.Preoperative hair removal to reduce surgical site infection[J]. Cochrane Database Syst Rev, 2021, 8(8):CD004122. DOI: 10.1002/14651858.CD004122.pub5. [42] Stambough JB, Nam D, Warren DK, et al. Decreased hospital costs and surgical site infection incidence with a universal decolonization protocol in primary total joint arthroplasty[J]. J Arthroplasty, 2017, 32(3):728-734.e1. DOI: 10.1016/j.arth.2016.09.041. [43] Lepelletier D, Maillard JY, Pozzetto B, et al.Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization[J]. Antimicrob Agents Chemother,2020,64(9):e00682-20. DOI: 10.1128/AAC.00682-20. [44] Fu Shaw L, Chen IH, Chen CS, et al.Factors influencing microbial colonies in the air of operating rooms[J]. BMC Infect Dis, 2018, 18(1):4. DOI:10.1186/s12879-017-2928-1. [45] Roth JA, Juchler F, Dangel M, et al.Frequent door openings during cardiac surgery are associated with increased risk for surgical site infection: a prospective observational study[J]. Clin Infect Dis, 2019, 69(2):290-294. DOI: 10.1093/cid/ciy879. [46] Webster J, Alghamdi A.Use of plastic adhesive drapes during surgery for preventing surgical site infection[J]. Cochrane Database Syst Rev, 2015, 2015(4):CD006353. DOI: 10.1002/14651858.CD006353.pub4. [47] de Jonge SW, Boldingh QJJ, Koch AH, et al. Timing of preoperative antibiotic prophylaxis and surgical site infection: TAPAS, an observational cohort study[J]. Ann Surg, 2021,274(4):e308-e314. DOI:10.1097/SLA.0000000000003634. [48] Pradeep A, Rangasamy J, Varma PK.Recent developments in controlling sternal wound infection after cardiac surgery and measures to enhance sternal healing[J]. Med Res Rev, 2021, 41(2):709-724. DOI: 10.1002/med.21758. [49] Suleiman AS, Abbass M, Hossain M, et al.Impact of antibiotic-coated sutures on surgical site infections: a second-order Meta-analysis[J]. Int J Surg, 2024, 110(1):507-519. DOI: 10.1097/JS9.0000000000000822. |
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