内分泌治疗对乳腺癌患者主客观认知功能影响的系统评价

doi:10.16460/j.issn1008-9969.2022.16.037

摘要/Abstract

摘要： 目的系统评价内分泌治疗对乳腺癌患者主客观认知功能的影响。方法计算机检索The Cochrane Library、Medline、Embase、CINAHL、PubMed、Web of Science、中国生物医学文献数据库、万方、维普和中国知网期刊数据库建库至2021年10月31日的文献,根据纳入和排除标进行文献筛选、资料提取和质量评价,最后对纳入的文献进行总结分析。结果共纳入11篇文献,结果显示,内分泌治疗对乳腺癌患者主客观认知功能影响的评定宜采用联合测试,客观认知表现以记忆力受损最为广泛,主客观认知功能影响的相关性较弱。结论内分泌治疗对乳腺癌患者认知功能的影响结果尚待进一步统一,提示需关注乳腺癌患者远期认知功能损伤,开展更多高质量研究,进一步验证分析。

关键词: 内分泌治疗, 乳腺癌, 认知功能, 系统评价

Abstract: Objective To systematically review the effects of endocrine therapy on subjective and objective cognitive function in patients with breast cancer. Methods Databases including The Cochrane Library, Medline, Embase, CINAHL, PubMed, Web of Science, SinoMed, Wanfang, VIP and CNKI were searched by computer from the inception to October 31, 2021. Data screening and extraction, quality evaluation, and summary and analysis of the included studies were carried out. Results Eleven studies were connected. Data analysis showed that the effect of endocrine therapy on the subjective and objective cognitive functions of breast cancer patients should be assessed by a combined test. Memory impairment was the most extensive objective cognitive performance, and the correlation between the effects of subjective and objective cognitive functions was weak. Conclusion There is no consensus on the effect of endocrine therapy on cognitive function in breast cancer patients yet, which indicates that more attention should be paid to long-term cognitive function impairment of breast cancer patients. More high-quality studies are needed for further confirmatory analysis.

Key words: endocrine therapy, breast cancer, cognitive function, systematic review

中图分类号:

R473.73

欧阳蝶, 杨洁, 于相宇, 袁晓玲. 内分泌治疗对乳腺癌患者主客观认知功能影响的系统评价[J]. 护理学报, 2022, 29(16): 37-42.

OUYANG Die, YANG Jie, YU Xiang-yu, YUAN Xiao-ling. Effects of Endocrine Therapy on Subjective and Objective Cognitive Function in Patients with Breast Cancer: A Systematic Review[J]. Journal of Nursing, 2022, 29(16): 37-42.

参考文献

[1] World Health Organization. Latest Global Cancer Data[EB/OL]. (2020-12-15). https://www.iarc.who.int/.
[2] Vannorsdall TD.Cognitive Changes Related to Cancer Therapy[J]. Med Clin North Am, 2017,101(6):1115-1134. DOI:10.1016/j.mcna.2017.06.006.
[3] Wu LM, Amidi A.Cognitive Impairment Following Hormone Therapy: Current Opinion of Research in Breast and Prostate Cancer Patients[J]. Curr Opin Support Palliat Care, 2017,11(1):38-45. DOI:10.1097/SPC.0000000000000251.
[4] 张扬,罗太珍,林燕珊,等. 妇科癌症患者癌症相关性认知功能损害的神经心理学研究[J]. 护理学报,2019,26(15):70-75. DOI:10.16460/j.issn1008-9969.2019.15.070.
[5] Dijkshoorn ABC, van Stralen HE, Sloots M, et al. Prevalence of Cognitive Impairment and Change in Patients with Breast Cancer: A Systematic Review of Longitudinal Studies[J]. Psychooncology,2021,30(5):635-648.DOI:10.1002/pon.5623.
[6] Yamamoto S, Masutani E, Arao H.Self-reported Cognitive Decline in Japanese Patients with Breast Cancer Treated with Endocrine Therapy[J]. Breast Cancer, 2020,27(4):670-682. DOI:10.1007/s12282-020-01062-7.
[7] Underwood EA, Rochon PA, Moineddin R, et al.Cognitive Sequelae of Endocrine Therapy in Women Treated for Breast Cancer: A Meta-analysis[J]. Breast Cancer Res Treat, 2018,168(2):299-310. DOI:10.1007/s10549-017-4627-4.
[8] Lo CK, Mertz D, Loeb M.Newcastle-Ottawa Scale: Comparing Reviewers' to Authors' Assessments[J]. BMC Med Res Methodol, 2014,14:45. DOI:10.1186/1471-2288-14-45.
[9] 周英凤,顾莺,胡雁,等. JBI循证卫生保健中心对关于不同类型研究的质量评价工具——患病率及分析性横断面研究的质量评价[J]. 护士进修杂志, 2018,33(3):219-221. DOI:10.16821/j.cnki.hsjx.2018.03.007.
[10] Underwood EA, Jerzak KJ, Lebovic G, et al.Cognitive Effects of Adjuvant Endocrine Therapy in Older Women Treated for Early-stage Breast Cancer: A 1-year Longitudinal Study[J]. Support Care Cancer, 2019,27(8):3035-3043. DOI:10.1007/s00520-018-4603-5.
[11] Biro E, Kahan Z, Kalman J, et al.Cognitive Functioning and Psychological Well-being in Breast Cancer Patients on Endocrine Therapy[J]. In Vivo, 2019,33(4):1381-1392. DOI:10.21873/invivo.11615.
[12] Chen X, He X, Tao L, et al.The Working Memory and Dorsolateral Prefrontal-hippocampal Functional Connectivity Changes in Long-term Survival Breast Cancer Patients Treated with Tamoxifen[J]. Int J Neuropsychopharmacol, 2017,20(5):374-382. DOI:10.1093/ijnp/pyx008.
[13] Chen X, Li J, Zhang J, et al.Impairment of The Executive Attention Network in Premenopausal Women with Hormone Receptor-positive Breast Cancer Treated with Tamoxifen[J]. Psychoneuroendocrinology,2017,75:116-123. DOI:10.1016/j.psyneuen.2016.10.020.
[14] Berndt U, Leplow B, Schoenfeld R, et al.Memory and Spatial Cognition in Breast Cancer Patients Undergoing Adjuvant Endocrine Therapy[J]. Breast Care (Basel), 2016,11(4):240-246. DOI:10.1159/000446901.
[15] Boele FW, Schilder CM, de Roode ML, et al. Cognitive Functioning During Long-term Tamoxifen Treatment in Postmenopausal Women with Breast Cancer[J]. Menopause, 2015,22(1):17-25. DOI:10.1097/GME.0000000000000271.
[16] Chen X, Li J, Chen J, et al.Decision-making Impairments in Breast Cancer Patients Treated with Tamoxifen[J]. Horm Behav, 2014,66(2):449-456. DOI:10.1016/j.yhbeh.2014.07.005.
[17] Lejbak L, Vrbancic M, Crossley M.Endocrine Therapy Is Associated with Low Performance on Some Estrogen-Sensitive Cognitive Tasks in Postmenopausal Women with Breast Cancer[J]. J Clin Exp Neuropsychol, 2010,32(8):836-846. DOI:10.1080/13803391003596389.
[18] Schilder CM, Seynaeve C, Beex LV, et al.Effects of Tamoxifen and Exemestane on Cognitive Functioning of Postmenopausal Patients with Breast Cancer: Results From the Neuropsychological Side Study of the Tamoxifen and Exemestane Adjuvant Multinational Trial[J]. J Clin Oncol, 2010,28(8):1294-1300. DOI:10.1200/JCO.2008.21.3553.
[19] Collins B, Mackenzie J, Stewart A, et al.Cognitive Effects of Hormonal Therapy in Early Stage Breast Cancer Patients: A Prospective Study[J]. Psychooncology, 2009,18(8):811-821. DOI:10.1002/pon.1453.
[20] Shilling V, Jenkins V, Fallowfield L, et al.The Effects of Hormone Therapy on Cognition in Breast Cancer[J].J Steroid Biochem Mol Biol, 2003,86(3-5):405-412. DOI:10.1016/j.jsbmb.2003.07.001.
[21] Bray VJ, Dhillon HM, Vardy JL.Systematic Review of Self-reported Cognitive Function in Cancer Patients Following Chemotherapy Treatment[J]. J Cancer Surviv, 2018,12(4):537-559. DOI:10.1007/s11764-018-0692-x.
[22] Wechsler D.Wechsler Adult Intelligence Scale-third Edition[M]. San Antonio: The Psychological Corporation, 1997.
[23] Meulen EF, Schmand B, van Campen JP, et al. The Seven Minute Screen: A Neurocognitive Screening Test Highly Sensitive to Various Types of Dementia[J]. J Neurol Neurosurg Psychiatry, 2004,75(5):700-705. DOI:10.1136/jnnp.2003.021055.
[24] Rasmusson DX, Zonderman AB, Kawas C,et al.Effects of Age and Dementia on the Trail Making Test[J]. Clin neuropsychol,1998,12(2):169-178. DOI:10.1076/clin.12.2.169.2005.
[25] Bender CM, Merriman JD, Gentry AL, et al.Patterns of Change in Cognitive Function with Anastrozole Therapy[J]. Cancer, 2015,121(15):2627-2636.DOI:10.1002/cncr.29393.[26] Rosen WG, Mohs RC, Davis KL. A New Rating Scale for Alzheimer's Disease[J]. Am J Psychiatry,1984, 141(11):1356-1364. DOI10.1176/ajp.141.11.1356.
[27] Aaronson NK, Ahmedzai S, Bergman B, et al.The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-life Instrument for Use in International Clinical Trials in Oncology[J]. J Natl Cancer Inst, 1993,85(5):365-376. DOI:10.1093/jnci/85.5.365.
[28] Winterling D, Crook T, Salama M, et al.A Self-rating Scale for Assessing Memory Loss[M].London: John Libbey Eurotext, 1986:482-486.
[29] Broadbent DE, Cooper PF, FitzGerald P, et al. The Cognitive Failures Questionnaire (CFQ) and Its Correlates[J]. Br J Clin Psychol, 1982,21(1):1-16.DOI:10.1111/j.2044-8260.1982.tb01421.x.
[30] Apple AC, Schroeder MP, Ryals AJ, et al.Hippocampal Functional Connectivity is Related to Self-reported Cognitive Concerns in Breast Cancer Patients Undergoing Adjuvant Therapy[J]. Neuroimage Clin, 2018,20:110-118. DOI:10.1016/j.nicl.2018.07.010.
[31] Hutchinson AD, Hosking JR, Kichenadasse G, et al.Objective and Subjective Cognitive Impairment Following Chemotherapy for Cancer: A Systematic Review[J]. Cancer Treat Rev, 2012,38(7):926-934. DOI:10.1016/j.ctrv.2012.05.002.

相关文章 15

[1]	伍丽华, 吴心雨, 赖湘瑜, 邓宝贵, 黄泽青, 赵耀, 廖源, 沈彩萍, 李瑜. 人工关节置换术后患者深静脉血栓风险预测模型的系统评价[J]. 护理学报, 2025, 32(3): 12-16.
[2]	李嘉琪, 莫文娟, 王一棋, 王洁, 李梦楠, 刘兴, 冯佳. 基于COSMIN方法对慢性疼痛患者恐动症坦帕评分表的系统评价[J]. 护理学报, 2025, 32(2): 56-62.
[3]	华晶, 张青月, 王燕, 程畅, 张秀丽, 张爱爱. 问题提示清单在乳腺癌手术患者中的应用研究[J]. 护理学报, 2024, 31(8): 18-22.
[4]	余璐, 黄晓沁, 刘琳, 袁嘉敏, 邬青. 心力衰竭患者30天非计划性再入院风险预测模型的系统评价[J]. 护理学报, 2024, 31(8): 43-48.
[5]	周越, 张杰, 潘宇帆, 戴雨, 孙羽健, 肖益, 余雨枫. 机械通气患者衰弱风险预测模型的系统评价[J]. 护理学报, 2024, 31(6): 56-61.
[6]	吴林梅, 梁志金, 刘瑞杰, 钟静静, 邱予骅. COPD患者运动康复促进和阻碍因素的系统评价-基于CFIR多层次理论[J]. 护理学报, 2024, 31(5): 44-49.
[7]	李佳萍, 朱云霞, 朱宇. 乳腺癌化疗患者症状群的范围综述[J]. 护理学报, 2024, 31(4): 60-64.
[8]	王丽云, 张明慧, 张新月, 沙凯辉. 产后压力性尿失禁风险预测模型的系统评价[J]. 护理学报, 2024, 31(3): 57-62.
[9]	姚婉晴, 杨立状, 陈旦旦, 张晚秋, 卢薇, 管翠红, 李海. 不同非药物干预措施改善乳腺癌患者疲乏效果的网状Meta分析[J]. 护理学报, 2024, 31(24): 37-43.
[10]	邓岚心, 张宇, 李敏锐, 高钰琳. 养老机构老年人认知功能与身体衰弱变化的交叉滞后分析[J]. 护理学报, 2024, 31(23): 8-12.
[11]	杨丽娜, 黄蓉, 姚梅琦, 王竹青, 徐怡婷, 谢佩敏. 产后母乳喂养行为中断风险预测模型的系统评价[J]. 护理学报, 2024, 31(23): 59-65.
[12]	章明阳, 刘京辉, 金雁, 徐文琪, 李斌飞, 黄珊, 杜李百合, 侯亚甜, 李小寒. 围手术期低体温风险预测模型的系统评价[J]. 护理学报, 2024, 31(22): 54-60.
[13]	李苗, 李红梅, 张俊, 李盼盼, 张宇彤, 王茜, 李沁瑶. 乳腺癌化疗患者自我倡权潜在类别及影响因素分析[J]. 护理学报, 2024, 31(20): 19-23.
[14]	张亦然, 王康美, 朱盛财, 朱璐, 黄沂. 中文版高血压患者自我管理评估工具的系统评价：基于COSMIN指南[J]. 护理学报, 2024, 31(19): 52-57.
[15]	施杨, 顾志娥, 朱彤, 喻静, 王林. 社会网络和自我忽视在老年缺血性脑卒中患者衰弱与认知功能间的链式中介效应[J]. 护理学报, 2024, 31(17): 40-45.

Metrics

Viewed

Full text

Abstract

Cited

Shared