衰弱和抑郁在肺癌化疗患者恐惧疾病进展与生活质量间的链式中介作用

doi:10.16460/j.issn1008-9969.2023.18.065

摘要/Abstract

摘要： 目的探讨衰弱和抑郁在肺癌化疗患者恐惧疾病进展和生活质量间的链式中介作用。方法便利抽样法调查安徽省某三级甲等医院呼吸与危重症医学科住院的309例肺癌化疗患者,使用恐惧疾病进展简化量表、中文版衰弱量表、患者健康问卷抑郁量表和简明健康测量量表对研究对象的恐惧疾病进展、衰弱、抑郁和生活质量进行调查,构建并检验链式中介模型。结果肺癌化疗患者恐惧疾病进展总分为27.00（20.00,32.00）分、衰弱发生率为37.5%、抑郁患病率为46.7%、生活质量总分为59.41（42.53,75.48）分。中介效应分析显示恐惧疾病进展对生活质量的间接效应显著,总间接效应为-0.319,衰弱的特定中介效应占总间接效应的9.7%;抑郁的特定中介效应占总间接效应的72.7%;衰弱和抑郁在肺癌化疗患者恐惧疾病进展和生活质量间的链式中介效应占总间接效应的17.6%。结论衰弱和抑郁在肺癌化疗患者恐惧疾病进展和生活质量间的多重中介效应成立。临床工作人员应加大对肺癌化疗患者恐惧疾病进展的关注度,采取干预措施防止过度恐惧,从而减少衰弱、抑郁等不良身心应对结局,提高个体的生活质量。

关键词: 肺癌, 恐惧疾病进展, 生活质量, 衰弱, 抑郁

中图分类号:

R473.73

崔静萍, 蒋燕, 赵姗姗. 衰弱和抑郁在肺癌化疗患者恐惧疾病进展与生活质量间的链式中介作用[J]. 护理学报, 2023, 30(18): 65-70.

CUI Jing-ping, JIANG Yan, ZHAO Shan-shan. Chain mediating effect of weakness and depression between fear of progression and quality of life[J]. Journal of Nursing, 2023, 30(18): 65-70.

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