腹腔镜下结肠癌根治术后患者住院时间延长预测模型的构建

陈元杏, 郭艳, 王宏浩, 刘杲

护理学报 ›› 2025, Vol. 32 ›› Issue (7) : 70-75.

PDF(999 KB)
PDF(999 KB)
护理学报 ›› 2025, Vol. 32 ›› Issue (7) : 70-75. DOI: 10.16460/j.issn1008-9969.2025.07.070
临床护理※外科护理

腹腔镜下结肠癌根治术后患者住院时间延长预测模型的构建

  • 陈元杏a, 郭艳b, 王宏浩a, 刘杲a
作者信息 +

Construction of prediction model for prolonged hospital stay in patients undergoing laparoscopic radical surgery for colon cancer

  • CHEN Yuanxinga, GUO Yanb, WANG Honghaoa, LIU Gaoa
Author information +
文章历史 +

摘要

目的 制定腹腔镜下结肠癌根治术后患者住院时间延长的预测模型。方法 按照7∶3的比例随机将369例患者分为建模组和验证组。应用建模组分析患者住院时间延长的危险因素,并建立风险预测模型。以受试者工作特征曲线(ROC曲线)法分析模型效能。采用验证组患者验证模型。结果 腹腔镜下结肠癌根治术后患者住院时间延长预测模型:Logit(P/1-P)=-0.155+0.321×年龄+0.067×BMI+0.092×术前肠梗阻+0.128×手术时间+0.185×术后医院获得性肺炎+-0.201×围术期应用非甾体抗炎药。基于建模集样本构建的住院时间延长预测模型的预测效能:ROC-AUC为0.871。验证集样本的分析结果:ROC-AUC为0.863。Delong检验比较建模集和验证集所得ROC-AUC,P=0.779。结论 本研究构建的腹腔镜下结肠癌根治术后患者住院时间延长预测模型,有较高的预测效能。

Abstract

Objective To develop a prediction model of prolonged hospital stay (PLOS) in patients undergoing laparoscopic radical surgery for colon cancer. Method A total of 369 patients were randomly divided into a modeling group and a validation group at a ratio of 7:3. The modeling group was used to analyze risk factors of PLOS and establish a risk prediction model. The model performance was evaluated using ROC curve, followed by external validation in the validation group. Results The prediction model for PLOS in patients undergoing laparoscopic radical resection for colon cancer was as follows: Logit (P/1-P)=-0.155 + 0.321 × age +0.067 × BMI + 0.092 × preoperative intestinal obstruction + 0.128 × surgery time + 0.185 × postoperative hospital acquired pneumonia + -0.201 × perioperative use of nonsteroidal anti-inflammatory drugs. The predictive performance of the model constructed from the modeling group demonstrated a ROC-AUC of 0.871. Validation set analysis yielded a ROC-AUC of 0.863. DeLong’s test comparing ROC-AUC values between modeling and validation group showed no statistically significant difference (P=0.779). Conclusion The PLOS prediction model constructed in this study demonstrates high predictive efficiency for patients undergoing laparoscopic radical surgery for colon cancer.

关键词

腹腔镜 / 结肠癌根治术 / 住院时间 / 预测模型

Key words

laparoscopy / radical surgery for colon cancer / length of hospital stay / prediction model

引用本文

导出引用
陈元杏, 郭艳, 王宏浩, 刘杲. 腹腔镜下结肠癌根治术后患者住院时间延长预测模型的构建[J]. 护理学报. 2025, 32(7): 70-75 https://doi.org/10.16460/j.issn1008-9969.2025.07.070
CHEN Yuanxing, GUO Yan, WANG Honghao, LIU Gao. Construction of prediction model for prolonged hospital stay in patients undergoing laparoscopic radical surgery for colon cancer[J]. Journal of Nursing. 2025, 32(7): 70-75 https://doi.org/10.16460/j.issn1008-9969.2025.07.070
中图分类号: R473.6   

参考文献

[1] Mocan L.Laparoscopic surgery for the treatment of colon cancer: the new standard?[J]. Eur Rev Med Pharmacol Sci actions,2021,25(12):4228-4235.DOI:10.26355/eurrev_202106_26128.
[2] Jo YY, Han JH, Park HW, et al.Prediction of prolonged length of hospital stay after cancer surgery using machine learning on electronic health records:retrospective cross-sectional study[J]. JMIR Med Inform,2021, 9(2):e23147. DOI:10.2196/23147.
[3] Hashmi SA, Raja MHR, Arif A, et al.Reducing post-operative length of stay, is it worth the effort?[J]. World J Surg,2024,48(5):1096-1101. DOI:10.1002/wjs.12115.
[4] Schneider EB, Hyder O, Brooke BS, et al.Patient readmission and mortality after colorectal surgery for colon cancer: impact of length of stay relative to other clinical factors[J]. J Am Coll Surg,2012,214(4):390-398. DOI:10.1016/j.jamcollsurg.2011.12.025.
[5] Tamagawa H, Numata M, Aoyama T, et al.Laparoscopic-assisted surgery versus open surgery for transverse colon cancer: a multicenter retrospective study[J]. J Cancer Res Ther,2022,18(4):898-902.DOI:10.4103/jcrt.JCRT_946_20.
[6] 吴佳瑶,王成立,周声宁,等.结肠癌根治术患者住院时间延长的围术期相关危险因素分析[J].岭南现代临床外科,2022,22(6):555-559. DOI:10.3969/j.issn.1009-976X.2022.06.005.
[7] Dadi HH, Habte N, Mulu Y.Length of hospital stay and associated factors among adult surgical patients admitted to surgical wards in amhara regional state comprehensive specialized hospitals,Ethiopia[J].PLoS One,2024,19(8):e0296143. DOI:10.1371/journal.pone.0296143.
[8] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,中华医学会《中华全科医师杂志》编辑委员会,内分泌系统疾病基层诊疗指南编写专家组.肥胖症基层诊疗指南(2019年)[J].中华全科医师杂志, 2020, 19(2):95-101. DOI:10.3760/cma.j.issn.1671-7368.2020.02.002.
[9] Zhao HQ, Fan SR, Sun JC.Delayed Wound Healing in the elderly and a new therapeutic target:CD271[J]. Curr Stem Cell Res Ther, 2024, 19(3):316-323. DOI:10.2174/1574888X18666230403083603.
[10] 姚晨晨,陈娟,杨雷.老年衰弱患者基于埃德蒙顿衰弱量表评估分层抗阻运动的效果观察[J].护理学报,2024,31(7):73-78. DOI:10.16460/j.issn1008-9969.2024.07.073.
[11] Gazdikova K, Fojtova A, Wsolova L, et al.Nutritional status and risk of malnutrition[J]. Bratisl Lek Listy, 2024,125(7) :399-403. DOI:10.4149/BLL_2024_61.
[12] Lee DU, Fan GH, Hastie DJ, et al.The clinical impact of malnutrition on the postoperative outcomes of patients undergoing colorectal resection surgery for colon or rectal cancer: propensity score matched analysis of 2011-2017 US hospitals[J]. Surg Oncol,2021,38:101587. DOI:10.1016/j.suronc.2021.101587.
[13] Zunzunegui JP, García MA, Cruz BM, et al.Impact of the implementation of a preoperative nutritional program for colorectal surgery patients[J]. Rev Esp Enferm Dig,2020,112(12):909-914. DOI:10.17235/reed.2020.6572/2019.
[14] 张乔,刘昌丹,鲁小小,等.基于理论域框架的护士临床应用指南规范实施肠内营养的障碍因素分析[J]. 护理学报,2023,30(20):63-67. DOI:10.16460/j.issn1008-9969.2023.20.063.
[15] Lee YH, Kim DH, Kim JS, et al.Risk Assessment of Postoperative Pneumonia in Cancer patients using a common data model[J]. Cancers (Basel), 2022,14(23):5988. DOI:10.3390/cancers14235988.
[16] Hoyuela C, Guillaumes S, Ardid J, et al.The impact of intracorporeal anastomosis in right laparoscopic colectomy in the surgical site infections and the hospital stay: a cohort study[J]. Updates Surg,2021,73(6):2125-2135. DOI:10.1007/s13304-021-00998-5.
[17] 岑磊磊. 结肠癌根治术后并发症的Clavien-Dindo分级及其危险因素分析[J].中国现代普通外科进展, 2021,24(9):706-710. DOI:10.3969/j.issn.1009-9905.2021.09.007.
[18] Boeding JRE, Gobardhan PD, Rijken AM, et al.Preoptimisation in patients with acute obstructive colon cancer (PREOCC)- a prospective registration study protocol[J]. BMC Gastroenterol, 2023, 23(1):186.DOI:10.1186/s12876-023-02799-z.
[19] Schootman M, Li Ch, Ying J, et al.Maximizing readmission reduction in colon cancer patients[J]. J Surg Res, 2024,295:587-596. DOI:10.1016/j.jss.2023.11.047.
[20] 刘春兰,陈涛,刘莉莉,等.老年结肠癌根治术患者术后瞻妄的相关因素分析[J].中国普外基础与临床杂志,2024,31(6):733-738. DOI:10.7507/1007-9424.202312038.
[21] Burlacu R, Bourdin V, Blin P, et al. Over-the-counter non-steroidal anti-inflammatory medications: Focus on the management of acute pain[J]. Therapie,2024,S0040-5957(24)00177-X. DOI:10.1016/j.therap.2024.10.061.

基金

国家自然科学基金项目(82360477)

PDF(999 KB)

Accesses

Citation

Detail

段落导航
相关文章

/